Single cell immunoprofile of synovial fluid in rheumatoid arthritis with TNF/JAK inhibitor treatment

Single cell immunoprofile of synovial fluid in rheumatoid arthritis with TNF/JAK inhibitor treatment

Abstract Numerous patients with rheumatoid arthritis (RA) manifest severe syndromes, including elevated synovial fluid volumes (SF) with abundant immune cells, which can be controlled by TNF/JAK inhibitors. Here, we apply single-cell RNA sequencing (scRNA-seq) and subsequent validations in SF from R...

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Bibliographic Details
Main Authors: Xuyang Xia, Chenjia He, Zhinan Xue, Yuelan Wang, Yun Qin, Zhixiang Ren, Yupeng Huang, Han Luo, Hai-Ning Chen, Wei-Han Zhang, Li-Bin Huang, Yunying Shi, Yangjuan Bai, Bei Cai, Lanlan Wang, Feng Zhang, Maoxiang Qian, Wei Zhang, Yang Shu, Geng Yin, Heng Xu, Qibing Xie
Format: Article
Language:English
Published: Nature Portfolio 2025-03-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-57361-0

Internet

https://doi.org/10.1038/s41467-025-57361-0

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