Diabetes Induces Cardiac Fibroblast Activation, Promoting a Matrix‐Preserving Nonmyofibroblast Phenotype, Without Stimulating Pericyte to Fibroblast Conversion

Diabetes Induces Cardiac Fibroblast Activation, Promoting a Matrix‐Preserving Nonmyofibroblast Phenotype, Without Stimulating Pericyte to Fibroblast Conversion

Background Interstitial and perivascular fibrosis may contribute to diabetes‐associated heart failure. Pericytes can convert to fibroblasts under conditions of stress and have been implicated in the pathogenesis of fibrotic diseases. We hypothesized that in diabetic hearts, pericytes may convert to...

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Bibliographic Details
Main Authors: Linda Alex, Izabela Tuleta, Anis Hanna, Nikolaos G. Frangogiannis
Format: Article
Language:English
Published: Wiley 2023-03-01
Series:Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Subjects:
cardiomyopathy
diabetes
fibroblasts
hyperglycemia
lineage tracing
pericytes
Online Access:https://www.ahajournals.org/doi/10.1161/JAHA.122.027463

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https://www.ahajournals.org/doi/10.1161/JAHA.122.027463

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