Screening for effective cell-penetrating peptides with minimal impact on epithelial cells and gut commensals in vitro

One of the biggest challenges for oral drug absorption is the epithelial barrier of the gastrointestinal tract. The use of cell-penetrating peptides (CPPs) to modulate the epithelial barrier function is known to be an effective strategy to improve drug absorption and bioavailability. In this study w...

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Bibliographic Details
Main Authors: Hitesh P. Gelli, Ruben Vazquez-Uribe, Morten Otto Alexander Sommer
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-11-01
Series:Frontiers in Pharmacology
Subjects:
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.1049324/full