Unveiling the dance of evolution: Pla-mediated cleavage of Ymt modulates the virulence dynamics of Yersinia pestis

Unveiling the dance of evolution: Pla-mediated cleavage of Ymt modulates the virulence dynamics of Yersinia pestis

ABSTRACT Yersinia pestis has recently evolved into a highly lethal flea-borne pathogen through the pseudogenization of extensive genes and the acquisition of exogenous plasmids. Particularly noteworthy are the newly acquired pPCP1 and pMT1 plasmids, which encode the virulence determinants Pla and Ye...

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Bibliographic Details
Main Authors: Gengshan Wu, Yazhou Zhou, Shiyang Cao, Yarong Wu, Tong Wang, Yu Zhang, Xiaoyi Wang, Yajun Song, Ruifu Yang, Zongmin Du
Format: Article
Language:English
Published: American Society for Microbiology 2024-08-01
Series:mBio
Subjects:
Pla protease
Yersinia murine toxin
cleavage
virulence dynamics
Online Access:https://journals.asm.org/doi/10.1128/mbio.01075-24

Internet

https://journals.asm.org/doi/10.1128/mbio.01075-24

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