Single-cell microglial transcriptomics during demyelination defines a microglial state required for lytic carcass clearance

Single-cell microglial transcriptomics during demyelination defines a microglial state required for lytic carcass clearance

Abstract Background Microglia regulate the response to injury and disease in the brain and spinal cord. In white matter diseases microglia may cause demyelination. However, how microglia respond and regulate demyelination is not fully understood. Methods To understand how microglia respond during de...

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Bibliographic Details
Main Authors: Sameera Zia, Brady P. Hammond, Martin Zirngibl, Anastasia Sizov, Charbel S. Baaklini, Sharmistha P. Panda, Madelene F. S. Ho, Kelly V. Lee, Apurba Mainali, Mena K. Burr, Sioned Williams, Andrew V. Caprariello, Christopher Power, Thomas Simmen, Bradley J. Kerr, Jason R. Plemel
Format: Article
Language:English
Published: BMC 2022-12-01
Series:Molecular Neurodegeneration
Subjects:
Microglia
Demyelination
Cuprizone
Phagocytosis
Single-cell RNA sequencing
Heterogeneity
Online Access:https://doi.org/10.1186/s13024-022-00584-2

Internet

https://doi.org/10.1186/s13024-022-00584-2

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