Schistosomiasis-associated pulmonary hypertension unveils disrupted murine gut–lung microbiome and reduced endoprotective Caveolin-1/BMPR2 expression

Schistosomiasis-associated pulmonary hypertension unveils disrupted murine gut–lung microbiome and reduced endoprotective Caveolin-1/BMPR2 expression

Schistosomiasis-associated Pulmonary Arterial Hypertension (Sch-PAH) is a life-threatening complication of chronic S. mansoni infection that can lead to heart failure and death. During PAH, the expansion of apoptosis-resistant endothelial cells (ECs) has been extensively reported; however, therapeut...

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Bibliographic Details
Main Authors: Ygor Marinho, Elizabeth S. Villarreal, Sammy Y. Aboagye, David L. Williams, Jun Sun, Claudia L. M. Silva, Sarah E. Lutz, Suellen D. Oliveira
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-10-01
Series:Frontiers in Immunology
Subjects:
schistosomiasis
endothelial cell
PAH
apoptosis
Cav-1
BMPR2
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1254762/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2023.1254762/full

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