Exploring the RING-catalyzed ubiquitin transfer mechanism by MD and QM/MM calculations.

Exploring the RING-catalyzed ubiquitin transfer mechanism by MD and QM/MM calculations.

Ubiquitylation is a universal mechanism for controlling cellular functions. A large family of ubiquitin E3 ligases (E3) mediates Ubiquitin (Ub) modification. To facilitate Ub transfer, RING E3 ligases bind both the substrate and ubiquitin E2 conjugating enzyme (E2) linked to Ub via a thioester bond...

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Bibliographic Details
Main Authors: Yunmei Zhen, Guangrong Qin, Cheng Luo, Hualiang Jiang, Kunqian Yu, Guanghui Chen
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4086935?pdf=render

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http://europepmc.org/articles/PMC4086935?pdf=render

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