CryoEM structures of open dimers of gyrase A in complex with DNA illuminate mechanism of strand passage

CryoEM structures of open dimers of gyrase A in complex with DNA illuminate mechanism of strand passage

Gyrase is a unique type IIA topoisomerase that uses ATP hydrolysis to maintain the negatively supercoiled state of bacterial DNA. In order to perform its function, gyrase undergoes a sequence of conformational changes that consist of concerted gate openings, DNA cleavage, and DNA strand passage even...

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Bibliographic Details
Main Authors: Katarzyna M Soczek, Tim Grant, Peter B Rosenthal, Alfonso Mondragón
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2018-11-01
Series:eLife
Subjects:
gyrase
topoisomerases
cryoEM
B. subtilis
structure
T-segment
Online Access:https://elifesciences.org/articles/41215

Internet

https://elifesciences.org/articles/41215

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