Transcriptomics and miRNomics data integration in lymphoblastoid cells highlights the key role of immune-related functions in lithium treatment response in Bipolar disorder

Transcriptomics and miRNomics data integration in lymphoblastoid cells highlights the key role of immune-related functions in lithium treatment response in Bipolar disorder

Abstract Background Bipolar Disorder (BD) is a complex mental disease characterized by recurrent episodes of mania and depression. Lithium (Li) represents the mainstay of BD pharmacotherapy, despite the narrow therapeutic index and the high variability in treatment response. However, although severa...

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Bibliographic Details
Main Authors: Nadia Cattane, Cindie Courtin, Elisa Mombelli, Carlo Maj, Cristina Mora, Bruno Etain, Frank Bellivier, Cynthia Marie-Claire, Annamaria Cattaneo
Format: Article
Language:English
Published: BMC 2022-10-01
Series:BMC Psychiatry
Subjects:
Bipolar disorder
Lymphoblastoid cell line
Lithium
Gene expression
microRNAs
Transcriptome and miRNome integrative analysis
Online Access:https://doi.org/10.1186/s12888-022-04286-3

Internet

https://doi.org/10.1186/s12888-022-04286-3

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