Urine volume to hydration volume ratio is associated with pharmacokinetics of high‐dose methotrexate in patients with primary central nervous system lymphoma

Urine volume to hydration volume ratio is associated with pharmacokinetics of high‐dose methotrexate in patients with primary central nervous system lymphoma

Abstract High‐dose methotrexate (HD‐MTX)‐based chemotherapy is the first‐line treatment for primary central nervous system lymphoma (PCNSL), but is associated with severe adverse effects, including myelosuppression and renal impairment. MTX is primarily excreted by the kidneys. Renal function calcul...

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Bibliographic Details
Main Authors: Tetsuichiro Isono, Daiki Hira, Aya Morikochi, Tadateru Fukami, Satoshi Ueshima, Kazuhiko Nozaki, Tomohiro Terada, Shin‐ya Morita
Format: Article
Language:English
Published: Wiley 2021-12-01
Series:Pharmacology Research & Perspectives
Subjects:
creatinine clearance
high‐dose methotrexate
hydration volume
population pharmacokinetics
primary central nervous system lymphoma
urine volume
Online Access:https://doi.org/10.1002/prp2.883

Internet

https://doi.org/10.1002/prp2.883

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