Identification of multiplicatively acting modulatory mutational signatures in cancer

Identification of multiplicatively acting modulatory mutational signatures in cancer

Abstract Background A deep understanding of carcinogenesis at the DNA level underpins many advances in cancer prevention and treatment. Mutational signatures provide a breakthrough conceptualisation, as well as an analysis framework, that can be used to build such understanding. They capture somatic...

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Bibliographic Details
Main Authors: Dovydas Kičiatovas, Qingli Guo, Miika Kailas, Henri Pesonen, Jukka Corander, Samuel Kaski, Esa Pitkänen, Ville Mustonen
Format: Article
Language:English
Published: BMC 2022-12-01
Series:BMC Bioinformatics
Subjects:
Mutational signatures
Modulatory processes
Cancer
Online Access:https://doi.org/10.1186/s12859-022-05060-8

Internet

https://doi.org/10.1186/s12859-022-05060-8

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