A Simple and Efficient Protocol for Proline-Catalysed Asymmetric Aldol Reaction

A Simple and Efficient Protocol for Proline-Catalysed Asymmetric Aldol Reaction

The proline-catalysed asymmetric aldol reaction is usually carried out in highly dipolar aprotic solvents (dimethylsulfoxide, dimethylformamide, acetonitrile) where proline presents an acceptable solubility. Protic solvents are generally characterized by poor stereocontrol (e.g., methanol) or poor r...

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Bibliographic Details
Main Authors: Marco Giuseppe Emma, Alice Tamburrini, Ada Martinelli, Marco Lombardo, Arianna Quintavalla, Claudio Trombini
Format: Article
Language:English
Published: MDPI AG 2020-06-01
Series:Catalysts
Subjects:
proline
organocatalysis
asymmetric aldol reaction
methanol/water mixtures
sustainability
Online Access:https://www.mdpi.com/2073-4344/10/6/649

Internet

https://www.mdpi.com/2073-4344/10/6/649

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