Mechanical force induces macrophage-derived exosomal UCHL3 promoting bone marrow mesenchymal stem cell osteogenesis by targeting SMAD1

Mechanical force induces macrophage-derived exosomal UCHL3 promoting bone marrow mesenchymal stem cell osteogenesis by targeting SMAD1

Abstract Background Orthodontic tooth movement (OTM), a process of alveolar bone remodelling, is induced by mechanical force and regulated by local inflammation. Bone marrow-derived mesenchymal stem cells (BMSCs) play a fundamental role in osteogenesis during OTM. Macrophages are mechanosensitive ce...

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Bibliographic Details
Main Authors: Panjun Pu, Shengnan Wu, Kejia Zhang, Hao Xu, Jiani Guan, Zhichun Jin, Wen Sun, Hanwen Zhang, Bin Yan
Format: Article
Language:English
Published: BMC 2023-03-01
Series:Journal of Nanobiotechnology
Subjects:
Macrophages
Orthodontic tooth movement
Osteogenesis
Mechanical force
Exosomes
UCHL3
Online Access:https://doi.org/10.1186/s12951-023-01836-z

Internet

https://doi.org/10.1186/s12951-023-01836-z

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