Up Front Unfolded Protein Response Combined with Early Protein Secretion Pathway Engineering in <i>Yarrowia lipolytica</i> to Attenuate ER Stress Caused by Enzyme Overproduction

Up Front Unfolded Protein Response Combined with Early Protein Secretion Pathway Engineering in <i>Yarrowia lipolytica</i> to Attenuate ER Stress Caused by Enzyme Overproduction

Engineering the yeast <i>Yarrowia lipolytica</i> as an efficient host to produce recombinant proteins remains a longstanding goal for applied biocatalysis. During the protein overproduction, the accumulation of unfolded and misfolded proteins causes ER stress and cell dysfunction in <...

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Bibliographic Details
Main Authors: Xingyu Zhu, Moying Li, Rui Zhu, Yu Xin, Zitao Guo, Zhenghua Gu, Liang Zhang, Zhongpeng Guo
Format: Article
Language:English
Published: MDPI AG 2023-11-01
Series:International Journal of Molecular Sciences
Subjects:
<i>Yarrowia lipolytica</i>
recombinant protein
ER stress
ER chaperones
translocation
Online Access:https://www.mdpi.com/1422-0067/24/22/16426

Internet

https://www.mdpi.com/1422-0067/24/22/16426

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