Single-Cell RNA Profiling of Human Skin Reveals Age-Related Loss of Dermal Sheath Cells and Their Contribution to a Juvenile Phenotype

Single-Cell RNA Profiling of Human Skin Reveals Age-Related Loss of Dermal Sheath Cells and Their Contribution to a Juvenile Phenotype

The dermal sheath (DS) is a population of mesenchyme-derived skin cells with emerging importance for skin homeostasis. The DS includes hair follicle dermal stem cells, which exhibit self-renewal and serve as bipotent progenitors of dermal papilla (DP) cells and DS cells. Upon aging, stem cells exhib...

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Bibliographic Details
Main Authors: Juliane M. D. Ahlers, Cassandra Falckenhayn, Nicholas Holzscheck, Llorenç Solé-Boldo, Sabrina Schütz, Horst Wenck, Marc Winnefeld, Frank Lyko, Elke Grönniger, Annette Siracusa
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-01-01
Series:Frontiers in Genetics
Subjects:
single-cell RNA sequencing
skin
fibroblasts
dermal sheath cells
aging
stem cells
Online Access:https://www.frontiersin.org/articles/10.3389/fgene.2021.797747/full

Internet

https://www.frontiersin.org/articles/10.3389/fgene.2021.797747/full

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