Peptidomes and Structures Illustrate How SLA-I Micropolymorphism Influences the Preference of Binding Peptide Length

Peptidomes and Structures Illustrate How SLA-I Micropolymorphism Influences the Preference of Binding Peptide Length

Polymorphisms can affect MHC-I binding peptide length preferences, but the mechanism remains unclear. Using a random peptide library combined with LC-MS/MS and de novo sequencing (RPLD-MS) technique, we found that two swine MHC-I molecules with high sequence homology, SLA-1*04:01 and SLA-1*13:01, ha...

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Bibliographic Details
Main Authors: Xiaohui Wei, Shen Li, Suqiu Wang, Guojiao Feng, Xiaoli Xie, Zhuolin Li, Nianzhi Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-02-01
Series:Frontiers in Immunology
Subjects:
MHC class I
micropolymorphism
binding peptide length
crystal structure
peptidomes
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.820881/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2022.820881/full

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