Development of fish liver PLHC-1 spheroids and its applicability to investigate the toxicity of plastic additives

Fish liver cell lines are valuable tools to understand the toxicity of chemicals in aquatic vertebrates. While conventional 2D cell cultures grown in monolayers are well established, they fail to emulate toxic gradients and cellular functions as in in-vivo conditions. To overcome these limitations,...

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Bibliographic Details
Main Authors: Tiantian Wang, Judith Desmet, Elisabet Pérez-Albaladejo, Cinta Porte
Format: Article
Language:English
Published: Elsevier 2023-07-01
Series:Ecotoxicology and Environmental Safety
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S0147651323005201