TGF-β induces GBM mesenchymal transition through upregulation of CLDN4 and nuclear translocation to activate TNF-α/NF-κB signal pathway

TGF-β induces GBM mesenchymal transition through upregulation of CLDN4 and nuclear translocation to activate TNF-α/NF-κB signal pathway

Abstract Glioblastoma (GBM) is the most common and aggressive primary malignant brain tumor. The unregulated expression of Claudin-4 (CLDN4) plays an important role in tumor progression. However, the biological role of CLDN4 in GBM is still unknown. This study aimed to determine whether CLDN4 mediat...

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Main Authors: Tengfeng Yan, Yinqiu Tan, Gang Deng, Zhiqiang Sun, Baohui Liu, Yixuan Wang, Fanen Yuan, Qian Sun, Ping Hu, Lun Gao, Daofeng Tian, Qianxue Chen
格式: 文件
语言:English
出版: Nature Publishing Group 2022-04-01
丛编:Cell Death and Disease
在线阅读:https://doi.org/10.1038/s41419-022-04788-8

因特网

https://doi.org/10.1038/s41419-022-04788-8

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