The UFMylation pathway is impaired in Alzheimer’s disease

The UFMylation pathway is impaired in Alzheimer’s disease

Abstract Background Alzheimer’s disease (AD) is characterized by the presence of neurofibrillary tangles made of hyperphosphorylated tau and senile plaques composed of beta-amyloid. These pathognomonic deposits have been implicated in the pathogenesis, although the molecular mechanisms and consequen...

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Bibliographic Details
Main Authors: Tingxiang Yan, Michael G. Heckman, Emily C. Craver, Chia-Chen Liu, Bailey D. Rawlinson, Xue Wang, Melissa E. Murray, Dennis W. Dickson, Nilufer Ertekin-Taner, Zhenkun Lou, Guojun Bu, Wolfdieter Springer, Fabienne C. Fiesel
Format: Article
Language:English
Published: BMC 2024-12-01
Series:Molecular Neurodegeneration
Subjects:
UFMylation
UFM1
UFSP2
Alzheimer’s disease
Tau
Brain
Online Access:https://doi.org/10.1186/s13024-024-00784-y

Internet

https://doi.org/10.1186/s13024-024-00784-y

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