CD20 mutations involving the rituximab epitope are rare in diffuse large B-cell lymphomas and are not a significant cause of R-CHOP failure

CD20 mutations involving the rituximab epitope are rare in diffuse large B-cell lymphomas and are not a significant cause of R-CHOP failure

Rituximab binds an epitope on the CD20 antigen, encompassed in exon 5 of the MS4A1 gene. We sequenced this region and correlated the presence of mutations with CD20 protein expression and response to R-CHOP in patients with diffuse large B-cell lymphoma: 264 diagnostic biopsies and 15 biopsies taken...

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Bibliographic Details
Main Authors: Nathalie A. Johnson, Stephen Leach, Bruce Woolcock, Ronald J. deLeeuw, Ali Bashashati, Laurie H. Sehn, Joseph M. Connors, Mukesh Chhanabhai, Angela Brooks-Wilson, Randy D. Gascoyne
Format: Article
Language:English
Published: Ferrata Storti Foundation 2009-03-01
Series:Haematologica
Online Access:https://haematologica.org/article/view/5196

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https://haematologica.org/article/view/5196

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