Inducible T-Cell Costimulator Ligand Plays a Dual Role in Melanoma Metastasis upon Binding to Osteopontin or Inducible T-Cell Costimulator

Inducible T-Cell Costimulator Ligand Plays a Dual Role in Melanoma Metastasis upon Binding to Osteopontin or Inducible T-Cell Costimulator

Recently, we demonstrated that inducible T-cell costimulator (ICOS) shares its unique ligand (ICOSL) with osteopontin (OPN), and OPN/ICOSL binding promotes tumor metastasis and angiogenesis in the 4T1 breast cancer model. Literature showed that OPN promotes melanoma metastasis by suppressing T-cell...

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Bibliographic Details
Main Authors: Davide Raineri, Giuseppe Cappellano, Beatrice Vilardo, Federica Maione, Nausicaa Clemente, Elena Canciani, Elena Boggio, Casimiro Luca Gigliotti, Chiara Monge, Chiara Dianzani, Renzo Boldorini, Umberto Dianzani, Annalisa Chiocchetti
Format: Article
Language:English
Published: MDPI AG 2021-12-01
Series:Biomedicines
Subjects:
osteopontin
ICOSL
melanoma
metastasis
tumor microenvironment
Online Access:https://www.mdpi.com/2227-9059/10/1/51

Internet

https://www.mdpi.com/2227-9059/10/1/51

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