RBD trimer mRNA vaccine elicits broad and protective immune responses against SARS-CoV-2 variants

RBD trimer mRNA vaccine elicits broad and protective immune responses against SARS-CoV-2 variants

Summary: With the rapid emergence and spread of SARS-CoV-2 variants, development of vaccines with broad and potent protectivity has become a global priority. Here, we designed a lipid nanoparticle-encapsulated, nucleoside-unmodified mRNA (mRNA-LNP) vaccine encoding the trimerized receptor-binding do...

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Bibliographic Details
Main Authors: Qingtai Liang, Yifeng Wang, Shuyuan Zhang, Jing Sun, Wenbo Sun, Jizhou Li, Yaping Liu, Mingxi Li, Lin Cheng, Yuhang Jiang, Ruoke Wang, Rui Zhang, Zihan Yang, Yifei Ren, Peng Chen, Peng Gao, Huayuan Yan, Zheng Zhang, Qi Zhang, Xuanling Shi, Jianbin Wang, Wanli Liu, Xinquan Wang, Bo Ying, Jincun Zhao, Hai Qi, Linqi Zhang
Format: Article
Language:English
Published: Elsevier 2022-04-01
Series:iScience
Subjects:
Health sciences
Virology
Immunology
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004222003133

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http://www.sciencedirect.com/science/article/pii/S2589004222003133

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