Postnatal Deletion of Bmal1 in Cardiomyocyte Promotes Pressure Overload Induced Cardiac Remodeling in Mice

Postnatal Deletion of Bmal1 in Cardiomyocyte Promotes Pressure Overload Induced Cardiac Remodeling in Mice

Background Mice with cardiomyocyte‐specific deletion of Bmal1, a core clock gene, had spontaneous abnormal cardiac metabolism, dilated cardiomyopathy, and shortened lifespan. However, the role of cardiomyocyte Bmal1 in pressure overload induced cardiac remodeling is unknown. Here we aimed to underst...

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Bibliographic Details
Main Authors: Qing Liang, Hu Xu, Min Liu, Lei Qian, Jin Yan, Guangrui Yang, Lihong Chen
Format: Article
Language:English
Published: Wiley 2022-07-01
Series:Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Subjects:
Bmal1
cardiac remodeling
circadian clock
fibrosis
hypertrophy
Online Access:https://www.ahajournals.org/doi/10.1161/JAHA.121.025021

Internet

https://www.ahajournals.org/doi/10.1161/JAHA.121.025021

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