Glutaredoxin‐1 promotes lymphangioleiomyomatosis progression through inhibiting Bim‐mediated apoptosis via COX2/PGE2/ERK pathway

Glutaredoxin‐1 promotes lymphangioleiomyomatosis progression through inhibiting Bim‐mediated apoptosis via COX2/PGE2/ERK pathway

Abstract Background Lymphangioleiomyomatosis (LAM) is a female‐predominant interstitial lung disease, characterized by progressive cyst formation and respiratory failure. Clinical treatment with the mTORC1 inhibitor rapamycin could relieve partially the respiratory symptoms, but not curative. It is...

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Bibliographic Details
Main Authors: Ya Feng, Tianjiao Li, Yin Li, Zhoujun Lin, Xiao Han, Xiaolin Pei, Yupeng Zhang, Fei Li, Juan Yang, Di Shao, Chenggang Li
Format: Article
Language:English
Published: Wiley 2023-07-01
Series:Clinical and Translational Medicine
Subjects:
apoptosis
Bim
glutaredoxin
lymphangioleiomyomatosis
oxidative stress
Online Access:https://doi.org/10.1002/ctm2.1333

Internet

https://doi.org/10.1002/ctm2.1333

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