MMP14 cleaves PTH1R in the chondrocyte-derived osteoblast lineage, curbing signaling intensity for proper bone anabolism

MMP14 cleaves PTH1R in the chondrocyte-derived osteoblast lineage, curbing signaling intensity for proper bone anabolism

Bone homeostasis is regulated by hormones such as parathyroid hormone (PTH). While PTH can stimulate osteo-progenitor expansion and bone synthesis, how the PTH-signaling intensity in progenitors is controlled is unclear. Endochondral bone osteoblasts arise from perichondrium-derived osteoprogenitors...

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Bibliographic Details
Main Authors: Tsz Long Chu, Peikai Chen, Anna Xiaodan Yu, Mingpeng Kong, Zhijia Tan, Kwok Yeung Tsang, Zhongjun Zhou, Kathryn Song Eng Cheah
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2023-03-01
Series:eLife
Subjects:
osteogenesis
bone mass
chondrocyte-osteoblast lineage
parathyroid hormone signaling
metalloproteinases
Online Access:https://elifesciences.org/articles/82142

Internet

https://elifesciences.org/articles/82142

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