Simulation and mechanistic investigation of the arrhythmogenic role of the late sodium current in human heart failure.

Heart failure constitutes a major public health problem worldwide. The electrophysiological remodeling of failing hearts sets the stage for malignant arrhythmias, in which the role of the late Na(+) current (I(NaL)) is relevant and is currently under investigation. In this study we examined the role...

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Bibliographic Details
Main Authors: Beatriz Trenor, Karen Cardona, Juan F Gomez, Sridharan Rajamani, Jose M Ferrero, Luiz Belardinelli, Javier Saiz
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3299678?pdf=render