Expression, regulation and function of phosphofructo-kinase/fructose-biphosphatases (PFKFBs) in glucocorticoid-induced apoptosis of acute lymphoblastic leukemia cells

<p>Abstract</p> <p>Background</p> <p>Glucocorticoids (GCs) cause apoptosis and cell cycle arrest in lymphoid cells and constitute a central component in the therapy of lymphoid malignancies, most notably childhood acute lymphoblastic leukemia (ALL). PFKFB2 (6-phosphofru...

Full description

Bibliographic Details
Main Authors: Schmidt Stefan, Rainer Johannes, Janjetovic Kristina, Carlet Michela, Panzer-Grümayer Renate, Mann Georg, Prelog Martina, Meister Bernhard, Ploner Christian, Kofler Reinhard
Format: Article
Language:English
Published: BMC 2010-11-01
Series:BMC Cancer
Online Access:http://www.biomedcentral.com/1471-2407/10/638