Identification of 10 genes on Candida albicans chromosome 5 that control surface exposure of the immunogenic cell wall epitope β-glucan and cell wall remodeling in caspofungin-adapted mutants

Identification of 10 genes on Candida albicans chromosome 5 that control surface exposure of the immunogenic cell wall epitope β-glucan and cell wall remodeling in caspofungin-adapted mutants

ABSTRACT Candida albicans is part of normal microbiota; however, it can cause superficial and life-threatening infections in immune-compromised individuals. As the use of drugs from the echinocandin (ECN) class for the treatment of candidiasis is increasing, resistance against ECNs is also emerging....

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Bibliographic Details
Main Authors: Sudisht K. Sah, Anshuman Yadav, Michael D. Kruppa, Elena Rustchenko
Format: Article
Language:English
Published: American Society for Microbiology 2023-12-01
Series:Microbiology Spectrum
Subjects:
Candida albicans
caspofungin adaptation
cell wall remodeling
1,3-β-glucan exposure
chromosome 5 genes
Online Access:https://journals.asm.org/doi/10.1128/spectrum.03295-23

Internet

https://journals.asm.org/doi/10.1128/spectrum.03295-23

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