Hypoionic Shock Facilitates Aminoglycoside Killing of Both Nutrient Shift- and Starvation-Induced Bacterial Persister Cells by Rapidly Enhancing Aminoglycoside Uptake

Hypoionic Shock Facilitates Aminoglycoside Killing of Both Nutrient Shift- and Starvation-Induced Bacterial Persister Cells by Rapidly Enhancing Aminoglycoside Uptake

Bacterial persister cells are phenotypic variants that exhibit transient antibiotic tolerance and play a leading role in chronic infections and the development of antibiotic resistance. Determining the mechanism that underlies persister formation and developing anti-persister strategies, therefore,...

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Bibliographic Details
Main Authors: Zhongyu Chen, Yuanyuan Gao, Boyan Lv, Fengqi Sun, Wei Yao, Yan Wang, Xinmiao Fu
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-09-01
Series:Frontiers in Microbiology
Subjects:
persister
antibiotic tolerance
aminoglycoside
antibiotic uptake
fumarate
hypoionic shock
Online Access:https://www.frontiersin.org/article/10.3389/fmicb.2019.02028/full

Internet

https://www.frontiersin.org/article/10.3389/fmicb.2019.02028/full

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