Cardiotoxic Effects Produced by Omeprazole and Methylene Blue in an Animal Model of Cardiac Ischemia and Reperfusion and Potential Implications for the Pharmacological Strategy for Vasoplegic Syndrome

Cardiotoxic Effects Produced by Omeprazole and Methylene Blue in an Animal Model of Cardiac Ischemia and Reperfusion and Potential Implications for the Pharmacological Strategy for Vasoplegic Syndrome

Defined as systemic hypotension caused by intense vasodilation due to the loss of systemic vascular resistance, vasoplegic syndrome (VS) is associated with elevated morbidity and mortality in humans. Although vasopressors such as norepinephrine and vasopressin are the first-choice drugs for VS treat...

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Main Authors: Erisvaldo Amarante de Araújo, Fernando Sabia Tallo, Alex Sandro Felisberto Oliveira, Gustavo Saad Silva El Toghlobi, Rafael Augusto Arantes, Rafael Balsimelli, Bruno Kehrwald-Balsimelli, Bianca Lorayne de Almeida Viana, Fernanda Sakata Matuda, Lucas Antonio Duarte Nicolau, Jand Venes Rolim Medeiros, Adriano Caixeta, Murched Omar Taha, Walter José Gomes, Afonso Caricati-Neto, Francisco Sandro Menezes-Rodrigues
Format: Article
Language:English
Published: MDPI AG 2024-03-01
Series:Biomedicines
Subjects:
vasoplegic syndrome
cardiac ischemia–reperfusion
methylene blue
omeprazole
cardiac arrhythmias
Online Access:https://www.mdpi.com/2227-9059/12/3/582

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https://www.mdpi.com/2227-9059/12/3/582

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