The transcription factors Runx3 and ThPOK cross-regulate acquisition of cytotoxic function by human Th1 lymphocytes

The transcription factors Runx3 and ThPOK cross-regulate acquisition of cytotoxic function by human Th1 lymphocytes

Cytotoxic CD4 (CD4CTX) T cells are emerging as an important component of antiviral and antitumor immunity, but the molecular basis of their development remains poorly understood. In the context of human cytomegalovirus infection, a significant proportion of CD4 T cells displays cytotoxic functions....

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Bibliographic Details
Main Authors: Yasmina Serroukh, Chunyan Gu-Trantien, Baharak Hooshiar Kashani, Matthieu Defrance, Thien-Phong Vu Manh, Abdulkader Azouz, Aurélie Detavernier, Alice Hoyois, Jishnu Das, Martin Bizet, Emeline Pollet, Tressy Tabbuso, Emilie Calonne, Klaas van Gisbergen, Marc Dalod, François Fuks, Stanislas Goriely, Arnaud Marchant
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2018-02-01
Series:eLife
Subjects:
cytotoxic CD4 T cell
Th1 differentiation
ThPOK
Runx3
T-bet
cytomegalovirus
Online Access:https://elifesciences.org/articles/30496

Internet

https://elifesciences.org/articles/30496

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