Crosstalk between microRNA expression and DNA methylation drives the hormone-dependent phenotype of breast cancer

Crosstalk between microRNA expression and DNA methylation drives the hormone-dependent phenotype of breast cancer

Abstract Background Abnormal DNA methylation is observed as an early event in breast carcinogenesis. However, how such alterations arise is still poorly understood. microRNAs (miRNAs) regulate gene expression at the post-transcriptional level and play key roles in various biological processes. Here,...

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Bibliographic Details
Main Authors: Miriam Ragle Aure, Thomas Fleischer, Sunniva Bjørklund, Jørgen Ankill, Jaime A. Castro-Mondragon, OSBREAC, Anne-Lise Børresen-Dale, Jörg Tost, Kristine K. Sahlberg, Anthony Mathelier, Xavier Tekpli, Vessela N. Kristensen
Format: Article
Language:English
Published: BMC 2021-04-01
Series:Genome Medicine
Subjects:
miRNA
Methylation
Omics integration
Breast cancer
Systems biology
Online Access:https://doi.org/10.1186/s13073-021-00880-4

Internet

https://doi.org/10.1186/s13073-021-00880-4

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