Dual Effect of Combined Metformin and 2-Deoxy-D-Glucose Treatment on Mitochondrial Biogenesis and PD-L1 Expression in Triple-Negative Breast Cancer Cells

Dual Effect of Combined Metformin and 2-Deoxy-D-Glucose Treatment on Mitochondrial Biogenesis and PD-L1 Expression in Triple-Negative Breast Cancer Cells

Metformin and 2-deoxy-D-glucose (2DG) exhibit multiple metabolic and immunomodulatory anti-cancer effects, such as suppressed proliferation or PD-L1 expression. Their combination or 2DG alone induce triple-negative breast cancer (TNBC) cell detachment, but their effects on mitochondria, crucial for...

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Bibliographic Details
Main Authors: Jernej Repas, Mateja Zupin, Maja Vodlan, Peter Veranič, Boris Gole, Uroš Potočnik, Mojca Pavlin
Format: Article
Language:English
Published: MDPI AG 2022-03-01
Series:Cancers
Subjects:
metformin
2-deoxy-D-glucose
triple-negative breast cancer
T cells
mitochondrial biogenesis
protein N-glycosylation
Online Access:https://www.mdpi.com/2072-6694/14/5/1343

Internet

https://www.mdpi.com/2072-6694/14/5/1343

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