The human TRPA1 intrinsic cold and heat sensitivity involves separate channel structures beyond the N-ARD domain

The human TRPA1 intrinsic cold and heat sensitivity involves separate channel structures beyond the N-ARD domain

The authors report how the cold and heat sensing properties of the pain receptor TRPA1 are separately modulated by the C-terminal intracellular domain, and in concert with either the S1–S4 or the S5–S6 transmembrane domain.

Bibliographic Details
Main Authors: Lavanya Moparthi, Viktor Sinica, Vamsi K. Moparthi, Mohamed Kreir, Thibaut Vignane, Milos R. Filipovic, Viktorie Vlachova, Peter M. Zygmunt
Format: Article
Language:English
Published: Nature Portfolio 2022-10-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-022-33876-8

Internet

https://doi.org/10.1038/s41467-022-33876-8

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