cPLA2 blockade attenuates S100A7-mediated breast tumorigenicity by inhibiting the immunosuppressive tumor microenvironment

cPLA2 blockade attenuates S100A7-mediated breast tumorigenicity by inhibiting the immunosuppressive tumor microenvironment

Abstract Background Molecular mechanisms underlying inflammation-associated breast tumor growth are poorly studied. S100A7, a pro-inflammatory molecule has been shown to enhance breast cancer growth and metastasis. However, the S100A7-mediated molecular mechanisms in enhancing tumor growth and metas...

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Bibliographic Details
Main Authors: Sanjay Mishra, Manish Charan, Rajni Kant Shukla, Pranay Agarwal, Swati Misri, Ajeet K. Verma, Dinesh K. Ahirwar, Jalal Siddiqui, Kirti Kaul, Neety Sahu, Kunj Vyas, Ayush Arpit Garg, Anum Khan, Wayne O. Miles, Jonathan W. Song, Nidhi Bhutani, Ramesh K. Ganju
Format: Article
Language:English
Published: BMC 2022-02-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Metastasis
Breast cancer
S100A7
cPLA2
PGE2
Tumor microenvironment
Online Access:https://doi.org/10.1186/s13046-021-02221-0

Internet

https://doi.org/10.1186/s13046-021-02221-0

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