Structure-guided insights into potential function of novel genetic variants in the malaria vaccine candidate PfRh5

Structure-guided insights into potential function of novel genetic variants in the malaria vaccine candidate PfRh5

Abstract The recent stall in the global reduction of malaria deaths has made the development of a highly effective vaccine essential. A major challenge to developing an efficacious vaccine is the extensive diversity of Plasmodium falciparum antigens. While genetic diversity plays a major role in imm...

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Bibliographic Details
Main Authors: Khadidiatou Mangou, Adam J. Moore, Laty Gaye Thiam, Aboubacar Ba, Alessandra Orfanó, Ife Desamours, Duncan Ndungu Ndegwa, Justin Goodwin, Yicheng Guo, Zizhang Sheng, Saurabh D. Patel, Fatoumata Diallo, Seynabou D. Sene, Mariama N. Pouye, Awa Thioub Faye, Alassane Thiam, Vanessa Nunez, Cheikh Tidiane Diagne, Bacary Djilocalisse Sadio, Lawrence Shapiro, Ousmane Faye, Alassane Mbengue, Amy K. Bei
Format: Article
Language:English
Published: Nature Portfolio 2022-11-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-022-23929-9

Internet

https://doi.org/10.1038/s41598-022-23929-9

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