Sensitization of Patient-Derived Colorectal Cancer Organoids to Photon and Proton Radiation by Targeting DNA Damage Response Mechanisms

Sensitization of Patient-Derived Colorectal Cancer Organoids to Photon and Proton Radiation by Targeting DNA Damage Response Mechanisms

Pathological complete response (pCR) has been correlated with overall survival in several cancer entities including colorectal cancer. Novel total neoadjuvant treatment (TNT) in rectal cancer has achieved pathological complete response in one-third of the patients. To define better treatment options...

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Bibliographic Details
Main Authors: Kristin Pape, Anna J. Lößner, Doreen William, Tabea Czempiel, Elke Beyreuther, Anna Klimova, Claudia Lehmann, Tim Schmäche, Sebastian R. Merker, Max Naumann, Anne-Marlen Ada, Franziska Baenke, Therese Seidlitz, Rebecca Bütof, Antje Dietrich, Mechthild Krause, Jürgen Weitz, Barbara Klink, Cläre von Neubeck, Daniel E. Stange
Format: Article
Language:English
Published: MDPI AG 2022-10-01
Series:Cancers
Subjects:
patient-derived organoid
colorectal cancer
chemoradiotherapy
3D cell culture
proton radiation
DNA damage response
Online Access:https://www.mdpi.com/2072-6694/14/20/4984

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https://www.mdpi.com/2072-6694/14/20/4984

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