A patterned human primitive heart organoid model generated by pluripotent stem cell self-organization

A patterned human primitive heart organoid model generated by pluripotent stem cell self-organization

Abstract Pluripotent stem cell-derived organoids can recapitulate significant features of organ development in vitro. We hypothesized that creating human heart organoids by mimicking aspects of in utero gestation (e.g., addition of metabolic and hormonal factors) would lead to higher physiological a...

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Bibliographic Details
Main Authors: Brett Volmert, Artem Kiselev, Aniwat Juhong, Fei Wang, Ashlin Riggs, Aleksandra Kostina, Colin O’Hern, Priyadharshni Muniyandi, Aaron Wasserman, Amanda Huang, Yonatan Lewis-Israeli, Vishal Panda, Sudin Bhattacharya, Adam Lauver, Sangbum Park, Zhen Qiu, Chao Zhou, Aitor Aguirre
Format: Article
Language:English
Published: Nature Portfolio 2023-12-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-023-43999-1

Internet

https://doi.org/10.1038/s41467-023-43999-1

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