Reduced renal sympathetic nerve activity contributes to elevated glycosuria and improved glucose tolerance in hypothalamus-specific Pomc knockout mice

Reduced renal sympathetic nerve activity contributes to elevated glycosuria and improved glucose tolerance in hypothalamus-specific Pomc knockout mice

Objective: Hypothalamic arcuate nucleus-specific pro-opiomelanocortin deficient (ArcPomc−/−) mice exhibit improved glucose tolerance despite massive obesity and insulin resistance. We demonstrated previously that their improved glucose tolerance is due to elevated glycosuria. However, the underlying...

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Bibliographic Details
Main Authors: Kavaljit H. Chhabra, Donald A. Morgan, Benjamin P. Tooke, Jessica M. Adams, Kamal Rahmouni, Malcolm J. Low
Format: Article
Language:English
Published: Elsevier 2017-10-01
Series:Molecular Metabolism
Subjects:
Hypothalamic POMC
Renal denervation
Glucose tolerance
Glycosuria
GLUT2
Sympathetic nervous system
Online Access:http://www.sciencedirect.com/science/article/pii/S2212877817303964

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http://www.sciencedirect.com/science/article/pii/S2212877817303964

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