Large cell neuroendocrine carcinoma transformation: A novel acquired drug resistance mechanism in colorectal adenocarcinoma

Abstract Acquired resistance is a major problem limiting the clinical efficacy of treatments for metastatic colorectal cancer (mCRC). Histological transformation is an important mechanism underlying the acquired resistance of non‐small cell lung cancer and prostate cancer to targeted therapy. Howeve...

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Bibliographic Details
Main Authors: Feng Du, Ying Han, Xiao Hu, Yanjie Xiao, Youwu Shi, Jing Sun, Zhiwei Sun, Ying Yang, Jing Yu, Xiaodong Zhang, Jun Jia
Format: Article
Language:English
Published: Wiley 2023-04-01
Series:Cancer Innovation
Subjects:
Online Access:https://doi.org/10.1002/cai2.57