T-cell repertoire diversity: friend or foe for protective antitumor response?

Abstract Profiling the T-Cell Receptor (TCR) repertoire is establishing as a potent approach to investigate autologous and treatment-induced antitumor immune response. Technical and computational breakthroughs, including high throughput next-generation sequencing (NGS) approaches and spatial transcr...

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Bibliographic Details
Main Authors: Nicla Porciello, Ornella Franzese, Lorenzo D’Ambrosio, Belinda Palermo, Paola Nisticò
Format: Article
Language:English
Published: BMC 2022-12-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Online Access:https://doi.org/10.1186/s13046-022-02566-0