Ratiometric sensing of BiP-client versus BiP levels by the unfolded protein response determines its signaling amplitude

Ratiometric sensing of BiP-client versus BiP levels by the unfolded protein response determines its signaling amplitude

Insufficient folding capacity of the endoplasmic reticulum (ER) activates the unfolded protein response (UPR) to restore homeostasis. Yet, how the UPR achieves ER homeostatic readjustment is poorly investigated, as in most studies the ER stress that is elicited cannot be overcome. Here we show that...

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Bibliographic Details
Main Authors: Anush Bakunts, Andrea Orsi, Milena Vitale, Angela Cattaneo, Federica Lari, Laura Tadè, Roberto Sitia, Andrea Raimondi, Angela Bachi, Eelco van Anken
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2017-12-01
Series:eLife
Subjects:
endoplasmic reticulum
unfolded protein response
proteostasis
Online Access:https://elifesciences.org/articles/27518

Internet

https://elifesciences.org/articles/27518

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