The 2nd sialic acid-binding site of influenza A virus neuraminidase is an important determinant of the hemagglutinin-neuraminidase-receptor balance.

The 2nd sialic acid-binding site of influenza A virus neuraminidase is an important determinant of the hemagglutinin-neuraminidase-receptor balance.

Influenza A virus (IAV) neuraminidase (NA) receptor-destroying activity and hemagglutinin (HA) receptor-binding affinity need to be balanced with the host receptor repertoire for optimal viral fitness. NAs of avian, but not human viruses, contain a functional 2nd sialic acid (SIA)-binding site (2SBS...

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Bibliographic Details
Main Authors: Wenjuan Du, Hongbo Guo, Vera S Nijman, Jennifer Doedt, Erhard van der Vries, Joline van der Lee, Zeshi Li, Geert-Jan Boons, Frank J M van Kuppeveld, Erik de Vries, Mikhail Matrosovich, Cornelis A M de Haan
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2019-06-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1007860

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https://doi.org/10.1371/journal.ppat.1007860

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