Titration of Androgen Signaling: How Basic Studies Have Informed Clinical Trials Using High-Dose Testosterone Therapy in Castrate-Resistant Prostate Cancer

Titration of Androgen Signaling: How Basic Studies Have Informed Clinical Trials Using High-Dose Testosterone Therapy in Castrate-Resistant Prostate Cancer

Since the Nobel Prize-winning work of Huggins, androgen ablation has been a mainstay for treatment of recurrent prostate cancer. While initially effective for most patients, prostate cancers inevitably develop the ability to survive, grow, and metastasize further, despite ongoing androgen suppressio...

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Bibliographic Details
Main Authors: Steven K. Nordeen, Lih-Jen Su, Gregory A. Osborne, Perry M. Hayman, David J. Orlicky, Veronica M. Wessells, Adrie van Bokhoven, Thomas W. Flaig
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:Life
Subjects:
prostate cancer
castrate-resistant prostate cancer
androgens
testosterone
androgen receptor
androgen signaling
Online Access:https://www.mdpi.com/2075-1729/11/9/884

Internet

https://www.mdpi.com/2075-1729/11/9/884

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