Influence of ADAM10 on prion protein processing and scrapie infectiosity in vivo

Influence of ADAM10 on prion protein processing and scrapie infectiosity in vivo

Both the cellular prion protein (PrPc) and the amyloid precursor protein (APP) are physiologically subjected to complex proteolytic processing events. While for APP the proteinases involved – alpha-, beta- and gamma-secretase – have been identified in vitro and in vivo, the cleavage of PrPc by now h...

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Bibliographic Details
Main Authors: Kristina Endres, Gerda Mitteregger, Elzbieta Kojro, Hans Kretzschmar, Falk Fahrenholz
Format: Article
Language:English
Published: Elsevier 2009-11-01
Series:Neurobiology of Disease
Subjects:
alpha-Secretase
Shedding
Prion disease
Neurotoxicity
Gliosis
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996109001752

Internet

http://www.sciencedirect.com/science/article/pii/S0969996109001752

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