Ritonavir-Mediated Induction of Apoptosis in Pancreatic Cancer Occurs via the RB/E2F-1 and AKT Pathways

Ritonavir-Mediated Induction of Apoptosis in Pancreatic Cancer Occurs via the RB/E2F-1 and AKT Pathways

Recent observations suggest a lower incidence of malignancies in patients infected with HIV during treatment with Highly Active Anti-Retroviral Therapy (HAART) utilizing protease inhibitors. We investigated the effects of ritonavir, a FDA approved HIV protease inhibitor, on proliferation of pancreat...

Full description

Bibliographic Details
Main Authors: Ramesh B. Batchu, Oksana V. Gruzdyn, Christopher S. Bryant, Aamer M. Qazi, Sanjeev Kumar, Sreedhar Chamala, Shu T. Kung, Ramana S. Sanka, Udaya S. Puttagunta, Donald W. Weaver, Scott A. Gruber
Format: Article
Language:English
Published: MDPI AG 2014-01-01
Series:Pharmaceuticals
Subjects:
ritonavir
pancreatic adenocarcinoma
AKT
retinoblastoma
2F-1
Online Access:http://www.mdpi.com/1424-8247/7/1/46

Internet

http://www.mdpi.com/1424-8247/7/1/46

Similar Items