Genome-wide association study and polygenic risk scores of retinal thickness across the cognitive continuum: data from the NORFACE cohort

Genome-wide association study and polygenic risk scores of retinal thickness across the cognitive continuum: data from the NORFACE cohort

Abstract Background Several studies have reported a relationship between retinal thickness and dementia. Therefore, optical coherence tomography (OCT) has been proposed as an early diagnosis method for Alzheimer’s disease (AD). In this study, we performed a genome-wide association study (GWAS) aimed...

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Main Authors: María Eugenia Sáez, Ainhoa García-Sánchez, Itziar de Rojas, Emilio Alarcón-Martín, Joan Martínez, Amanda Cano, Pablo García-González, Raquel Puerta, Clàudia Olivé, Maria Capdevila, Fernando García-Gutiérrez, Miguel Castilla-Martí, Luis Castilla-Martí, Ana Espinosa, Montserrat Alegret, Mario Ricciardi, Vanesa Pytel, Sergi Valero, Lluís Tárraga, Mercè Boada, Agustín Ruiz, Marta Marquié
Format: Article
Language:English
Published: BMC 2024-02-01
Series:Alzheimer’s Research & Therapy
Subjects:
Alzheimer’s disease (AD)
Optical coherence tomography (OCT)
Genome-wide association study (GWAS)
Polygenic risk score (PRS)
Mendelian randomization (MR)
NORFACE
Online Access:https://doi.org/10.1186/s13195-024-01398-8

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https://doi.org/10.1186/s13195-024-01398-8

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