Icariside Ⅱ Attenuates Palmitic Acid-Induced Endothelial Dysfunction Through SRPK1-Akt-eNOS Signaling Pathway

Icariside Ⅱ Attenuates Palmitic Acid-Induced Endothelial Dysfunction Through SRPK1-Akt-eNOS Signaling Pathway

Background: Endothelial dysfunction is commonly accompanied by a reduced capacity for nitric oxide (NO) production and decreased NO sensitivity, playing a central role in numerous vascular diseases. Saturated free fatty acids are known to reduce NO production and then induce endothelial dysfunction....

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Bibliographic Details
Main Authors: Yang-Yang Gu, Xiao-Hui Tan, Wen-Peng Song, Wei-Dong Song, Yi-Ming Yuan, Zhong-Cheng Xin, Jia-Dong Wang, Dong Fang, Rui-Li Guan
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-06-01
Series:Frontiers in Pharmacology
Subjects:
endothelial dysfunction
icariside Ⅱ
palmitic acid
SRPK1-Akt-eNOS signaling pathway
nitric oxide
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.920601/full

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https://www.frontiersin.org/articles/10.3389/fphar.2022.920601/full

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