Dendritic cells reveal a broad range of MHC class I epitopes for HIV-1 in persons with suppressed viral load on antiretroviral therapy.

HIV-1 remains sequestered during antiretroviral therapy (ART) and can resume high-level replication upon cessation of ART or development of drug resistance. Reactivity of memory CD8(+) T lymphocytes to HIV-1 could potentially inhibit this residual viral replication, but is largely muted by ART in re...

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Bibliographic Details
Main Authors: Xiao-Li Huang, Zheng Fan, LuAnn Borowski, Robbie B Mailliard, Morgane Rolland, James I Mullins, Richard D Day, Charles R Rinaldo
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-09-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2944894?pdf=render