The role of GPD1L, a sodium channel interacting gene, in the pathogenesis of Brugada Syndrome

The role of GPD1L, a sodium channel interacting gene, in the pathogenesis of Brugada Syndrome

BackgroundBrugada Syndrome (BrS) is an inherited arrhythmia syndrome in which mutations in the cardiac sodium channel SCN5A (NaV1.5) account for approximately 20% of cases. Mutations in sodium channel-modifying genes may account for additional BrS cases, though BrS may be polygenic given common SNPs...

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Bibliographic Details
Main Authors: Alexander M. Greiner, Haider Mehdi, Chloe Cevan, Rebecca Gutmann, Barry London
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-06-01
Series:Frontiers in Medicine
Subjects:
inherited arrhythmia syndrome
Brugada Syndrome (BrS)
sudden cardiac death (SCD)
exome sequencing
genetics
arrhythmia
Online Access:https://www.frontiersin.org/articles/10.3389/fmed.2023.1159586/full

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https://www.frontiersin.org/articles/10.3389/fmed.2023.1159586/full

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